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M94A3052.TXT
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1994-10-25
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Document 3052
DOCN M94A3052
TI Reducing the variation in CD4 lymphocyte count measurements.
DT 9412
AU Raboud JM; Haley L; Montaner JS; Murphy C; Januszewska M; Schechter MT;
Univ of British Columbia, Vancouver.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):164 (abstract no. PB0082). Unique
Identifier : AIDSLINE ICA10/94369523
AB OBJECTIVE: To quantify the variation in CD4 counts of HIV infected
individuals due to laboratory and physiological factors and to find
strategies to reduce variation. METHODS: Blood was drawn from 30 HIV +ve
clinically stable men 3 times in each of 2 weeks, 4 weeks apart. At each
visit, 2 tubes of blood were drawn. Duplicate measurements were
performed on one of the blood samples. RESULTS: The coefficients of
variation of CD4 counts due to physiologic and laboratory factors were
13.3 (95% CI: 12.0, 15.1) and 5.6 (95% CI: 5.2, 6.1) respectively. Thus
laboratory factors accounted for 15% of the variation between visits.
Variation in the absolute WBC, lymphocyte % and CD4% accounted for 52%,
29% and 19% of the physiologic variation in CD4 counts respectively.
CONCLUSIONS: Our results confirm a high degree of variability of CD4
counts among HIV infected individuals, largely attributable to
physiological factors. This variability can be minimized more
effectively by repeating CD4 counts over time than by repeating
measurements at a single visit. Our data further suggest that the
variability of CD4 counts can be reduced by 80%, and at lower cost, if a
single CD4 fraction is utilized with the lymphocyte count repeated over
time.
DE Adult Human HIV Seropositivity/CLASSIFICATION/DIAGNOSIS/*IMMUNOLOGY
*Leukocyte Count Male Quality Control Reproducibility of Results T4
Lymphocytes/*IMMUNOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).